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The effectiveness of REVATIO in pulmonary hypertension PH secondary to sickle cell anemia has not been established.Bivariate logistic regression and stepwise logistic regression were used to determine if any baseline sildenafil citrates 20mg tablets or post-baseline measurements were associated with the patients' treatment preference. Baseline variables examined were age, race, ED aetiology/duration, body mass index, smoking status, alcohol consumption, vital signs, comorbid medical conditions, and baseline scores for the International Index of Erectile Function IIEF domains, Psychological and Interpersonal Relationship Scales PAIRS domains, and Sexual Encounter Profile SEP diary questions.

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It was postulated that nitric oxide inhalation therapy is associated with negative-feedback inhibition of nitric oxide synthase activity, resulting in a rapid decrease in pulmonary vascular smooth muscle cGMP when the gas is withdrawn abruptly.Adjustments to the initial titrated dose may be required if the underlying cause of ED progresses or if ED improves.

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n at least one patient with hypertrophic cardiomyopathy, decreased sildenafil tab 20mg pressure, marked reductions in ventricular dimensions, increased ejection fraction and subaortic gradient at rest, ventricular premature complexes, and unsustained ventricular tachycardia occurred following sildenafil administration for the treatment of ED. A precipitous sildenafil tab 20mg in blood pressure may occur with nitrate or nitrite use over the initial 24 hours following a dose of sildenafil; therefore, such sildenafil tab 20mg therapy is contraindicated.There were three subjects with a decrease from baseline in standing systolic BP 30mmHg following sildenafil 25 mg, one subject with a decrease from baseline in standing systolic BP 30 mmHg following placebo and two subjects with a decrease from baseline in standing systolic BP 30 mmHg following both sildenafil and placebo.

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