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Overall, escitalopram, mirtazapine, sertraline, and venlafaxine were significantly more efficacious than fluoxetine or the other medications. Bupropion, citalopram, escitalopram, and sertraline were better tolerated than the other antidepressants.The exact mechanism of the antidepressant action of venlafaxine in humans is unknown, but is thought to be related to the potentiation of effexor for add and anxiety and norepinephrine in the central nervous system, through inhibition of their reuptake.
Non- clinical studies have demonstrated that venlafaxine and its active metabolite, ODV, are potent and selective inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake.
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