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42- 2, -dichlorophenyl aminobenzeneacetic acid, monosodium salt.Approximately 65% of the dose is excreted in the urine and approximately 35% in the bile as conjugates of unchanged diclofenac plus metabolites. Because renal elimination is not a significant pathway of elimination for unchanged diclofenac, dosing adjustment in patients with mild to moderate renal dysfunction is not necessary.
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Do not share this medication with others.Co-administration of diclofenac with CYP2C9 inhibitors e. voriconazole may enhance the exposure and toxicity of diclofenac whereas co-administration with CYP2C9 inducers e.
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2015 Jan. 51.In the placebo-controlled trials, the discontinuation rate due to adverse reactions was 5% for patients treated with diclofenac sodium topical gel, and 3% for patients in the placebo group.
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The text how much is diclofenac sodium topical gel version may be available in large print, Braille or audio CD. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. This medicine has been prescribed for you only.The optimum times for making the first and subsequent transaminase measurements are not known.
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NSAIDs, including diclofenac, cause serious gastrointestinal GI adverse events including inflammation, bleeding, ulceration, and perforation of the esophagus, stomach, small intestine, or large intestine, which can be fatal. These serious adverse events can occur at any time, with or without warning symptoms, in patients treated with NSAIDs.Diclofenac concentrations reached during therapy have produced in vivo effects.
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Therefore, treatment with diclofenac sodium topical solution is not recommended in patients with advanced renal disease.When these drugs are administered concomitantly, patients should be adequately hydrated.
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