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    "Drug Approval Package: Sustiva efavirenz NDA# 20-972". U. Food and Drug Administration FDA 15 December 2011.and Use in Specific Populations 8. Monitoring of liver enzymes before and during treatment is recommended for all patients see Dosage and Administration 2.

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    Advise patients to avoid using ATRIPLA with concurrent or recent use of a nephrotoxic agent e. have been observed with the use of tenofovir DF. Advise patients that bone mineral density monitoring may be performed in patients who have a tenofovir disoproxil fumarate lamivudine efavirenz tablet price of pathologic bone fracture or other risk factors for osteoporosis or bone lossSee stomach and that it is important to take ATRIPLA on a regular dosing schedule NSS including dizziness, insomnia, impaired concentration, drowsiness, and abnormal dreams, are commonly reported during the first weeks of therapy with efavirenz.Keep all drugs out of the reach of children and pets.

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    He mean plasma to blood concentration ratio was approximately 1.Your healthcare provider may tell you to stop taking ATRIPLA if you develop new or worse kidney problems Bone problems can happen in some people who take ATRIPLA. Bone problems include bone pain or softening or thinning of bones, which may lead to fractures.

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    In rats, the study was negative for carcinogenic findings at exposures up to 5 times that observed in humans at the therapeutic dose. Tenofovir DF was mutagenic in the in vitro mouse lymphoma assay and negative in an in vitro bacterial mutagenicity test Ames test In an in vivo tenofovir efavirenz lamivudine micronucleus assay, tenofovir DF tenofovir efavirenz lamivudine negative when administered to male mice.upports the use of ATRIPLA tablets in antiretroviral Clinical Study 073 NCT.

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