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Examples of NSAIDs include ibuprofen, naproxen, diclofenac and celecoxib. “ Estimates of increased risk range from 10% to 50% or more, ...: FDA strengthens NSAID label warnings for heart attack, stroke ...

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Clinical data
Pronunciation/ ˈ aɪ b juː p r oʊ f ɛ n /, / aɪ b juː ˈ p r oʊ f ən /, EYE -bew- PROH -fən
Trade namesAdvil, Motrin, Nurofen, others
License dataEU  EMA:  by INN, US   FDA: Ibuprofen
Pregnancy categoryAU: C US: C (Risk not ruled out) D (US) at ≥30 weeks of gestation, due to the potential for premature closure of the ductus arteriosus
Routes of administrationby mouth, rectal, topical, and intravenous
ATC codeC01EB16 ( WHO ) G02CC01 ( WHO ) M01AE01 ( WHO ) M02AA13 ( WHO ) R02AX02 ( WHO )
Legal status
Legal statusAU: OTC CA : OTC UK: General sales list (GSL, OTC) US: OTC (R x -only at higher doses)
Pharmacokinetic data
Bioavailability80–100% (by mouth), [2] 87% (rectal)
Protein binding98% [1]
MetabolismLiver (CYP2C9) [1]
Metabolitesibuprofen glucuronide, 2-hydroxyibuprofen, 3-hydroxyibuprofen, carboxy-ibuprofen, 1-hydroxyibuprofen
Onset of action30 min [3]
Elimination half-life2–4 h [4]
ExcretionUrine (95%) [1] [5]

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J Neurosci. reshwater JD, Svensson CI, Malmberg AB, Calcutt NA. Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats.See WARNINGS IBU, a nonsteroidal anti-inflammatory drug NSAID is availablein 400 mg, 600 mg, and 800 mg tablets for oral administration.

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