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|Trade names||Phenergan, many others |
|Pregnancy category||AU: C US: C (Risk not ruled out)|
|Routes of administration||By mouth, rectal, IV, IM, topical|
|ATC code||D04AA10 ( WHO ) R06AD02 ( WHO )|
|Legal status||AU: S3 (Pharmacist only) CA : OTC UK: P (Pharmacy medicines) (POM when injection), US: ℞-only South Africa: S5 IV S2 Oral|
|Bioavailability||88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability |
|Metabolism||Liver glucuronidation and sulfoxidation|
|Elimination half-life||16–19 hours  |
|Excretion||Kidney and biliary|
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Data sources include IBM Watson Micromedex updated 10 Aug 2020 Cerner Multum updated 3 Aug 2020 Wolters Kluwer updated 10 Aug 2020 andothers.
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Complete disclaimerDo not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.Who should not take Promethazine Hydrochloride and Codeine Phosphate Oral Solution?
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Hyperpyrexia, hypotension, and death have been reported coincident with the coadministration of monoamine oxidase MAO inhibitors and products containing dextromethorphan.t is important to tell your doctor about all other medications you use, including vitamins and herbs. o not stop using any medication without first talking to your doctor.
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