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Clinical data
Trade namesPhenergan, many others [1]
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth, rectal, IV, IM, topical
ATC codeD04AA10 ( WHO ) R06AD02 ( WHO )
Legal status
Legal statusAU: S3 (Pharmacist only) CA : OTC UK: P (Pharmacy medicines) (POM when injection), US: ℞-only South Africa: S5 IV S2 Oral
Pharmacokinetic data
Bioavailability88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability [2]
Protein binding93%
MetabolismLiver glucuronidation and sulfoxidation
Elimination half-life16–19 hours [2] [3]
ExcretionKidney and biliary

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Antihistamines: Chlorphenamine, Hydroxyzine, Promethazine. • Mean (SD) age = 83 (7) years, 63% women. • 14,224 (35%) cases and 84,751 (30%) controls ...: Anticholinergic Cognitive Burden scale - UEA

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Hyperpyrexia, hypotension, and death have been reported coincident with the coadministration of monoamine oxidase MAO inhibitors and products containing dextromethorphan.t is important to tell your doctor about all other medications you use, including vitamins and herbs. o not stop using any medication without first talking to your doctor.

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