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Clinical data
Pronunciation/ m ɛ t r ə ˈ n aɪ d ə z oʊ l /
Trade namesFlagyl, Metro, others
License dataUS   FDA: Metronidazole
Pregnancy categoryAU: B2 US: B (No risk in non-human studies)
Routes of administrationby mouth, topical, rectal, IV, vaginal
ATC codeA01AB17 ( WHO ) D06BX01 ( WHO ), G01AF01 ( WHO ), J01XD01 ( WHO ), P01AB01 ( WHO ), QP51AA01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability80% (by mouth), 60–80% (rectal), 20–25% (vaginal) [1] [2]
Protein binding20% [1] [2]
MetabolismHepatic [1] [2]
Elimination half-life8 hours [1] [2]
ExcretionUrine (77%), faeces (14%) [1] [2]

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ACOG Halo Bulletin No. Vaginitis.

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Dysuria, cystitis, polyuria, incontinence, and a sense of pelvic pressure. Instances of darkened urine have been reported by approximately one patient in.2.

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Although some clinicians suggest use of oral tetracycline or oral erythromycin followed by a luminal amebicide for the metronidazole effect on birth control of mild or less severe metronidazole effect on birth control in patients who cannot tolerate metronidazole, this regimen will not eradicate trophozoites in the liver.

Metronidazole and tinidazole are not recommended for treatment of asymptomatic cyst passers because of limited activity against encysted E. histolytica.While it's only approved by the U. Food and Drug Administration for use in humans, veterinarians might prescribe it for their patients "off-label. Don't give metronidazole to pregnant or lactating animals.

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Additionally, the efficacy of this therapy is also dependent on the length of time that it is given.Gastroenterology.

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Cosmetics may be applied to the skin after application of metronidazole 1% topical gel, 0. 5 or 1% topical cream, or 0.Scand J Gastroenterol.

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You may report side effects to the FDA at 1-800-FDA-1088.If you have frequent recurrences or a chronic kidney infection, you may be referred to a doctor who specializes in urinary disorders urologist or kidney disorders nephrologist for an evaluation. Ask if there's anything you need to do in advance, such as collect a urine specimen.

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