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    Jcts. 1PubMed CrossRef Google Scholar 84.Most included studies suggested improvement in PFWD and TWD for pentoxifylline over placebo and other treatments, but the statistical and clinical significance of findings from individual trials is unclear. Pentoxifylline generally was well tolerated; the most commonly reported side effects consisted of gastrointestinal symptoms such as nausea.

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    Entoxifylline, 60 placebo xclusions post pentoxifylline er 400mg 59Losses to follow up: noneAge: pentoxifylline: 62 9 years, placebo: 61 8 yearsSex: M: pentoxifylline: 46: 9, placebo: 28: 2Inclusion criteria: intermittent claudication with total walking distance 400 m; claudication 3 months; Doppler ankle brachial index 0.

    decrease in ankle pressure 20 mm Hg after standard exercise test on treadmill; age between 50 and 65 years; arterial stenoses, plaques and flow reduction on colour duplex imagingExclusion criteria: presence of Indication for revascularisation or angioplasty; angina or myocardial ischaemia on effort; previous coronary or vascular surgery or angioplasty, aneurysms, congestive heart failure NYHA III/IV, renal failure creatinine 2 mg/dL IDDM II; pentoxifylline er 400mg other pulmonary cardiac neoplastic disease or inflammatory or immunologic diseaseInterventionsTreatment: oral pentoxifylline, 600 mg 3 times dailyControl: placeboDuration: pentoxifylline er 400mg monthsOutcomesPrimary: mean TWDSecondary: side effectsNotesTreadmill protocol: 3 km/h at 12% pentoxifylline er 400mg TWD expressed in metres onlyParticipants also took 300 mg antiplatelets as pentoxifylline er 400mg of study treatmentRisk of biasBiasAuthors' judgementSupport for judgementRandom sequence generation selection bias nclear riskStates 'patients were randomised into two treatment plans'; no other information providedAllocation concealment selection bias nclear riskNot mentionedBlinding of participants and personnel performance bias All outcomesUnclear riskInsufficient information provided to permit judgementBlinding of outcome assessment detection bias All outcomesUnclear riskNo information on dropouts provided other than due to low complianceSelective reporting reporting bias nclear riskNo information on dropouts provided pentoxifylline er 400mg than due to low complianceOther biasUnclear riskPentoxifylline dose unclear; study authors report both 1600 mg and 1800 mg.6 Nevertheless, results of our previous study indicate that changes of at pentoxifylline er 400mg 15% over baseline should have been detectable in the present study.

    6 Of the 40 subjects, 4 receiving pentoxifylline and 3 receiving placebo discontinued prematurely.

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    Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine.Walking capacity is one of the most important outcome measures used to assess pentoxifylline er claudication. According to Moher 2000, walking capacity can be assessed by pain free walking distance PFWD or initial claudication distance ICD which is the distance walked on a treadmill before the onset of pain; and total walking distance TWD or absolute claudication distance ACD which is pentoxifylline er maximum or absolute distance walked on a treadmill.

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    It pentoxifylline er also negative in the in vivo mouse micronucleus test. Teratogenicity studies have been performed in rats and rabbits using oral doses up to 576 and pentoxifylline er mg/kg, respectively.Angelkort B. Influence of pentoxifylline Trental 400 on microcirculation, poststenotic blood pressure and walking capacity in patients with chronic occlusive arterial disease.

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    Fold, respectively, with a 400 mg pentoxifylline extended-release tablets TID regimen. The increase in exposure to Metabolite V is only slightly smaller in both pentoxifylline er impairment pentoxifylline er if pentoxifylline extended-release tablets are administered BID. Pentoxifylline Extended-Release Tablets are indicated for the treatment of patients with intermittent claudication on the basis of chronic occlusive arterial disease of the limbs.97.

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    Kiesewetter 1988 was judged at high risk of bias because TWD results were reported pentoxifylline er 400mg the abstract but were not mentioned in the remainder of the paper, either as an outcome variable or as a result.Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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