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Data sources include IBM Watson Micromedex updated 10 Aug 2020 Cerner Multum updated 3 Aug 2020 Wolters Kluwer updated 10 Aug 2020 andothers. odeine/phenylephrine/promethazine is a member of the akorn promethazine hydrochloride oral solution respiratory combinations drug class and is commonly used for Cough and Nasal Congestion.Disclaimer: Information presented in this database is not meant as a substitute for professional judgment.

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Sedating drugs may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of Promethazine HCl Suppositories and observed closely.5 times the MRHD on a mg/m2 basis with maternal intraperitoneal and subcutaneous doses up to 1 mg/kg/day In pregnant rats dosed during the period of organogenesis from gestation days 5 to 16, promethazine hydrochloride induced complete resorption at doses approximately 6 times the MRHD on a mg/m2 basis with maternal oral doses up to 20 mg/kg/day In pregnant rats dosed during the period of organogenesis from gestation days 7 to 13, promethazine resulted in skeletal fragility of pups at doses approximately 3 times the MRHD on a mg/m2 basis with maternal oral doses up to 10 mg/kg/day In pregnant rats dosed during the period of organogenesis from gestation days 10 to 12, promethazine resulted in decreased weight and delays in akorn promethazine hydrochloride oral solution occurrence of behavioral/reflex of pups at doses akorn promethazine hydrochloride oral solution 3 times the MRHD on a mg/m2 basis with akorn promethazine hydrochloride oral solution oral doses up to 10 mg/kg/day Because of the akorn promethazine hydrochloride oral solution for serious adverse reactions, including excess sedation, respiratory depression, and death in a breastfed infant, advise patients that breastfeeding is not recommended during treatment with Promethazine with Codeine Oral Solutionsee Warnings and Precautions 5.

There are no data on the presence of Promethazine with Codeine Oral Solution in human milk, the effects of Promethazine with Codeine Oral Solution on the breastfed infant, or the effects of Promethazine with Codeine Oral Solution on milk production; however, data are available with codeine and promethazine.

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