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Clinical data
Trade namesPhenergan, many others [1]
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth, rectal, IV, IM, topical
ATC codeD04AA10 ( WHO ) R06AD02 ( WHO )
Legal status
Legal statusAU: S3 (Pharmacist only) CA : OTC UK: P (Pharmacy medicines) (POM when injection), US: ℞-only South Africa: S5 IV S2 Oral
Pharmacokinetic data
Bioavailability88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability [2]
Protein binding93%
MetabolismLiver glucuronidation and sulfoxidation
Elimination half-life16–19 hours [2] [3]
ExcretionKidney and biliary

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CONDITIONS OF USE: he information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. he information is not intended to cover all promethazine dog uses, directions, precautions, drug interactions or adverse promethazine dogs, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else.There are no animal or human data concerning the carcinogenicity, mutagenicity, or impairment of fertility with these drugs.

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