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Tamoxifen
Clinical data
Trade namesNolvadex, Genox, Tamifen, others [1]
AHFS/Drugs.comMonograph
MedlinePlusa682414
Pregnancy categoryAU: B3 US: D (Evidence of risk)
Routes of administrationBy mouth
Drug classSelective estrogen receptor modulator
ATC codeL02BA01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Protein binding99%
MetabolismHepatic (CYP3A4, 2C9 and 2D6)
Elimination half-life5-7 days [2]
ExcretionFeces: 65% Urine: 9%

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4-Hydroxytamoxifen and a side chain primary alcohol derivative of tamoxifen have been identified as minor metabolites in plasma. Tamoxifen is a substrate of cytochrome P-450 3A, 2C9 and 2D6, and an inhibitor of P-glycoprotein.However, all groups of Pdx1PB-CreERTm; 26RlacZ islets transplanted into Tm-treated mice showed recombination rates higher than vehicle-treated controls, independent of Tm dose or time of transplantation.

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-fold greater incidence of endometrial cancer than tamoxifen fors sale uk on the placebo arm 36 invasive cancers among women receiving tamoxifen versus endometrial cancers diagnosed among women on the tamoxifen arm of this trial were stage I, and the majority 75% were diagnosed among women who were 50 years of age or older.Results are shown in Table 1.

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